Publications

65. T. Wang, L. Xu, H. Shen, X. Cao, Q. Wei, R. A. Ghiladi, and Q. Wang “Photoinactivation of Bacteria by Hypocrellin-Grafted Bacterial Cellulose” Cellulose 2019, in press.

64. B. Peddinti, F. Scholle, R. A. Ghiladi and R. Spontak “Antimicrobial Thermoplastic Elastomers: Strategic Pathways for the Future of Broad-Spectrum Anti-Infective Materials” Rubber World 2019, 161, 67-77.

63. E. Feese, Hanna S. Gracz, Paul D. Boyle and R. A. Ghiladi “Towards Microbe-targeted Photosensitizers: Synthesis, Characterization and In vitro Photodynamic Inactivation of the Tuberculosis Model Pathogen M. smegmatis by Porphyrin-Peptide Conjugates” J. Porphyr. Phthalocyanines 2019, in press.

62. T. Malewschik, V. de Serrano, A. H. McGuire and R. A. Ghiladi “The Multifunctional Globin Dehaloperoxidase Strikes Again: Simultaneous Peroxidase and Peroxygenase Mechanisms in the Oxidation of EPA Pollutants” Arch. Biochem. Biophys. 2019, 673, 108079.

61. T. Moreno-Chicano, A. Ebrahim, D. Axford, M. V. Appleby, J. Beale, A. K. Chaplin, H. M. E. Duyvesteyn, R. A. Ghiladi, S. Owada, D. A. Sherrell, R. W. Strange, H. Sugimoto, K. Tono, J. A. R. Worrall, R. L. Owen and M. A. Hough “High Throughput Structures of Protein-Ligand Complexes at Room Temperature using Serial Femtosecond Crystallography” IUCrJ 2019, 6, 1074–1085.

60. W. Chen, J. Chen, L. Li, X. Wang, Q. Wei, R. A. Ghiladi, and Q. Wang “Wool/Acrylic Blended Fabrics as Next Generation Photodynamic Antimicrobial Materials” ACS Appl. Mater. Interfaces 2019, 11, 29557−29568.

59. B. Peddinti, F. Scholle, R. A. Ghiladi and R. Spontak “Inherently Self-Sterilizing Charged Multiblock Polymers that Kill Drug-Resistant Microbes in Minutes” Materials Horizons 2019, in press.
(see the highlights of this paper in Chemistry World here, in C&E News here, and by the NCSU News Service here)

58. K. R. Stoll, F. Scholle, J. Zhu, X. Zhang and R. A. Ghiladi, “BODIPY-Embedded Electrospun Materials in Antimicrobial Photodynamic Inactivation,” Photochem. Photobiol. Sci. 2019, 18, 1923-1932 (invited).

57. D. R. Alvarado, D. S. Argyropoulos, F. Scholle, B. Peddinti and R. A. Ghiladi, “A Facile Strategy for Photoactive Nanocellulose-based Antimicrobial Materials,” Green Chemistry 2019, 21, 3424-3435.

56. C. Jiang, F. Scholle and R. A. Ghiladi, “Mn-doped Zn/S quantum dots as photosensitizers for antimicrobial photodynamic inactivation,” Proc. S.P.I.E. 2019, vol. 10863, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II, 108630Q; DOI: 10.1117/12.2510934.

55. P. Chariou, L. Wang, C. Desai, J. Park, L. K. Robbins, H. A. von Recum, R. A. Ghiladi and N. F. Steinmetz “Let There Be Light: Targeted Photodynamic Therapy Using High Aspect Ratio Plant Viral Nanoparticles” Macromol. Biosci. 2019, 1800407.

54. B. Peddinti, F. Scholle, R. A. Ghiladi and R. Spontak “Photodynamic Polymers as Comprehensive Anti-Infective Materials: Staying Ahead of a Growing Global Threat” ACS Appl. Mater. Interfaces 2018, 10, 25955-25959.

53. A. McGuire, L. M. Carey, V. de Serrano, S. Dali and R. A. Ghiladi “Peroxidase vs. Peroxygenase Activity: Substrate Substituent Effects as Modulators of Enzyme Function in the Multifunctional Catalytic Globin Dehaloperoxidase” Biochemistry 2018, 57, 4455-4468.

52. W. Chen, W. Wang, X. Ge, Q. Wei, R. A. Ghiladi, and Q. Wang “Photo-Oxidation Properties of Photosensitizer/Direct Dye Patterned Polyester/Cotton Fabrics” Fiber Polym. 2018, 19, 1687–1693.

51. Q. Wang, W. Chen, Q. Zhang, R. A. Ghiladi and Q. Wei “Preparation of Photodynamic P(MMA-co-MAA) Composite Nanofibers Doped with MMT: A Facile Method for Increasing Antimicrobial Efficiency” Appl. Surf. Sci. 2018, 457, 247-255.

50. J. Dong, R. A. Ghiladi, Q. Wang, Y. Cai, and Q. Wei “Protoporphyrin-IX Conjugated Cellulose Nanofibers that Exhibit High Antibacterial Photodynamic Inactivation Efficacy” Nanotechnology 2018, 29, 265601.

49. J. Dong, R. A. Ghiladi, Q. Wang, Y. Cai, and Q. Wei “Protoporphyrin-IX Conjugated Bacterial Cellulose via Diamine Spacer Arms with Specific Antibacterial Photodynamic Inactivation Against Escherichia coli” Cellulose 2018, 25, 1673–1686.

48. L. M. Carey, K.-b. Kim, N. McCombs, P. Swartz, C. Kim, and R. A. Ghiladi “Selective Tuning of Activity in a Multifunctional Enzyme as Revealed in the F21W Mutant of Dehaloperoxidase B from Amphitrite ornata” J. Biol. Inorg. Chem. 2018,23, 209-219.

47. L. M. Carey, R. Gavenko, D. A. Svistunenko, and R. A. Ghiladi “How Nature Tunes Isoenzyme Activity in the Multifunctional Catalytic Globin Dehaloperoxidase from Amphitrite ornataBBA Proteins Proteom. 2018, 1866, 230–241.

46. H. Masarapu, B. Patel, P. Chariou, H. Hu, N. Gulati, B. L. Carpenter, R. A. Ghiladi, S. Shukla, and N. F. Steinmetz “Physalis mottle virus-like particles as nanocarriers for imaging reagents and drugs” Biomacromolecules 2017, 18, 4141–4153.

45. N. L. McCombs, T. Smirnova, and R. A. Ghiladi “Oxidation of Pyrrole by Dehaloperoxidase-Hemoglobin: Chemoenzymatic Synthesis of Pyrrolin-2-Ones” Catal. Sci. Technol. 2017, 7, 3104-3118.

44. J. D. Wallat, K. Wek, P. Chariou, B. L. Carpenter, R. A. Ghiladi, N. F. Steinmetz and J. K. Pokorski “Fluorinated Polymer-Photosensitizer Conjugates Enable Improved Generation of ROS for Anticancer Photodynamic Therapy” Polymer Chem. 2017, 8, 3195-3202.

43. N. L. McCombs, T. Moreno-Chicano, L. M. Carey, S. Franzen, M. A. Hough, and R. A. Ghiladi “Interaction of Azole-based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: a Molecular Basis for Toxicity” Biochemistry 2017, 56, 2294–2303.

42. X. Du, L. A. Lucia, and R. A. Ghiladi “Development of an efficient and economical pretreatment sequence for the enzymatic saccharification of loblolly pine wood” ACS Sustainable Chem. Eng. 20164, 3669–3678.

41. S. L. Stanley, F. Scholle, J. Zhu, Y. Lu, X. Zhang, X. Situ, and R. A. Ghiladi “Photosensitizer-Embedded Polyacrylonitrile Nanofibers as an Antimicrobial Non-Woven Textile” Nanomaterials20166, 77.

40. N. L. McCombs, L. M. Carey, J. D’Antonio, D. A. Barrios, and R. A. Ghiladi “Non-microbial Nitrophenol Degradation via Peroxygenase Activity of Dehaloperoxidase-Hemoglobin from Amphitrite ornataBiochemistry 2016, 55, 2465–2478.

39. A. M. Wen, P. Cao, K. L. Lee, K. Pangilinan, B. L. Carpenter, R. A. Ghiladi, R. C. Advincula, and N. F. Steinmetz “Utilizing viral nanoparticle/dendron hybrid conjugates in photodynamic therapy for dual delivery to macrophages and cancer cells” Bioconjugate Chem. 201627, 1227–1235.

38. K. L. Lee, B. L. Carpenter, A. M. Wen, R. A. Ghiladi, and N. F. Steinmetz “A TMV-based Photosensitizer for Imaging and Treatment of Aggressive Melanoma” ACS Biomater. Sci. Eng.20162, 838–844.

37. X. Du, L. A. Lucia, and R. A. Ghiladi “A Novel Approach for the Rapid Preparation of Monophasic Microemulsions that Facilitates the Penetration of Woody Biomass” ACS Sustainable Chem. Eng. 20164, 1665-1672.

36. S. Franzen, R. A. Ghiladi, L. Lebioda, and J. Dawson “Chapter 10: Multi-functional hemoglobin dehaloperoxidases” in Heme Peroxidases; The Royal Society of Chemistry: 2015, p 218-244 (invited chapter).

35. B. L. Carpenter, F. Scholle, H. Sadeghifar, A. J. Francis, J. Boltersdorf, W. W. Weare, D. S. Argyropoulos, P. A. Maggard, and R. A. Ghiladi “Synthesis, Characterization, and Antimicrobial Efficacy of Photomicrobicidal Cellulose Paper” Biomacromolecules 2015, 16, 2482-2492.

34. B. L. Carpenter, X. Situ, F. Scholle, J. Bartelmess, W. W. Weare, and R. A. Ghiladi “Antiviral, Antifungal and Antibacterial Activities of a BODIPY-based Photosensitizer” Molecules 2015, 20, 10604-10621 (invited).

33. D. K. Muli, B. L. Carpenter, M. Mayukh, R. A. Ghiladi, D. V. McGrath “Dendritic near-IR absorbing zinc phthalocyanines for antimicrobial photodynamic therapy” Tetrahedron Lett. 2015, 56, 3541–3545.

32. D. Barrios, J. D’Antonio, N. L. McCombs, J. Zhao, S. Franzen, A. Schmidt, L. Sombers, and R. A. Ghiladi “Peroxygenase and Oxidase Activities of Dehaloperoxidase-Hemoglobin from Amphitrite ornata” J. Am. Chem. Soc. 2014, 136, 7914-7925.

31. R. Dumarieh, J. D’Antonio, A. Liang, T. Smirnova, D. A. Svistunenko, and R. A. Ghiladi “Tyrosyl Radicals in Dehaloperoxidase: How Nature Deals with Evolving an Oxygen Binding Globin to a Biologically-Relevant Peroxidase” J. Biol. Chem. 2013, 288, 33470–33482.

30. J. Zhao, V. de Serrano, R. Dumarieh, R. A. Ghiladi, M. K. Thompson, and S. Franzen “The Role of the Distal Histidine in H2O2 Activation and Heme Protection in Both Peroxidase and Globin Functions” J. Phys. Chem. 2012, 116, 12065-12077.

29. B. L. Carpenter, E. Feese, H. Sadeghifar, D. S. Argyropoulos, and R. A. Ghiladi “Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity” Photochem. Photobiol. 2012, 88, 527-536 (invited).

28. D. A. Svistunenko, J. Worrall, S. Chugh, S. Haigh, R. A. Ghiladi, and P. Nicholls “Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: their stability and interplay with pH” Biochimie 2012, 94, 1274-1280.

27. S. Franzen, K. Sasan, B. E. Sturgeon, B. J. Lyon, B. Batternberg, H. Gracz, R. Dumarieh, and R. A. Ghiladi “Non-Photochemical Base-Catalyzed Hydroxylation of 2,6-Dichloroquinone by H2O2 Occurs by a Radical Mechanism” J. Phys. Chem. B 2012, 116, 1666-1676.

26. S. Franzen, M. K. Thompson, and R. A. Ghiladi “The Dehaloperoxidase Paradox” Biochim. Biophys. Acta. 2012, 1824, 578-588.

25. R. A. Ghiladi, A. L. Rheingold, M. A. Siegler, and K. D. Karlin “Synthesis and characterization of new trinuclear copper complexes” Inorg. Chim. Acta 2012, 389, 131-137.

24. E. L. D’Antonio, J. D’Antonio, V. De Serrano, H. Gracz, M. K. Thompson, R. A. Ghiladi, E. F. Bowden, and S. Franzen “Functional Consequences of the Creation of an Asp-His-Fe Triad in a 3/3 Globin.” Biochemistry 2011, 50, 9664-9680.

23. E. Feese, H. Sadeghifar, H. Gracz, D. S. Argyropoulos, and R. A. Ghiladi “Photobactericidal Porphyrin-Cellulose Nanocrystals: Synthesis, Characterization and Antimicrobial Properties” Biomacromolecules 2011, 12, 3528-3539.

22. J. D’Antonio and R. A. Ghiladi “Reactivity of Deoxy- and Oxyferrous Dehaloperoxidase B from Amphitrite ornata: Identification of Compound II and its Ferrous-Hydroperoxide Precursor” Biochemistry 2011, 50, 5999-6011.

21. M. K. Thompson, S. Franzen, R. A. Ghiladi, B. Reeder, and D. A. Svistunenko “Compound ES of Dehaloperoxidase Decays via Two Alternative Pathways Depending on the Conformation of the Distal Histidine” J. Am. Chem. Soc., 2010, 132, 17501-17510.

20. J. D’Antonio, E. L. D’Antonio, M. K. Thompson, E. F. Bowden, S. Franzen, T. Smirnova, and R. A. Ghiladi “Spectroscopic and Mechanistic Investigations of Dehaloperoxidase B from Amphitrite ornata” Biochemistry 2010, 49, 6600-6616.

19. V. De Serrano, J. D’Antonio, S. Franzen, and R. A. Ghiladi “Structure of Dehaloperoxidase B at 1.58 Å Resolution and Structural Characterization of the A/B Dimer from Amphitrite ornata” Acta Cryst. 2010, D66, 529-538.

18. C. E. Cade, A. C. Dlouhy, K. F. Medzihradszky, S. P. Salas-Castillo, and R. A. Ghiladi “Isoniazid-Resistance Conferring Mutations in Mycobacterium tuberculosis KatG: Catalase, Peroxidase, and INH-NADH Adduct Formation Activities” Protein Sci., 2010, 19, 458-474.

17. E. Feese and R. A. Ghiladi “Highly Efficient Photodynamic Inactivation of Mycobacterium smegmatis” J. Antimicrob. Chemother. 2009, 64, 782-785.

16. J. Feducia, R. Dumarieh, L. B. G. Gilvey, T. Smirnova, S. Franzen, and R. A. Ghiladi “Characterization of Dehaloperoxidase Compound ES and its Reactivity with Trihalophenols” Biochemistry 2009, 48, 995-1005.

15. D. Maiti, J. S. Woertink, R. A. Ghiladi, E. I. Solomon, and Karlin, K. D. “Molecular Oxygen and Sulfur Reactivity of a Cyclotriveratrylene Derived Trinuclear Copper(I) Complex” Inorg. Chem. 2009, 48, 8342-8356.

14. R. A. Ghiladi, E. Chufan, D. del Río, E. I. Solomon, C. Krebs, B. H. Huynh, H.-w. Huang, P. Moënne-Loccoz, S. Kaderli, M. Honecker, A. D. Zuberbühler, L. Marzilli, R. J. Cotter, and K. D. Karlin “Further Insights into the Spectroscopic Properties, Electronic Structure and Kinetics of Formation of the Heme-Peroxo-Copper Complex [(F8TPP)FeIII-(O22–)-CuII(TMPA)]+Inorg. Chem. 2007, 46, 3889-3902.

13. R. A. Ghiladi, K. F. Medzihradszky, and P. R. Ortiz de Montellano “The Role of the Met-Tyr-Trp Crosslink in Mycobacterium tuberculosis Catalase-Peroxidase (KatG) as Revealed by KatG(M255I)” Biochemistry 2005, 44, 15093-15105.

12. R. A. Ghiladi, K. F. Medzihradszky, F. M. Rusnak, and P. R. Ortiz de Montellano “Correlation Between Isoniazid Resistance and Superoxide Reactivity in Mycobacterium tuberculosis KatG” J. Am. Chem. Soc. 2005, 127, 13428-13442.

11. R. A. Ghiladi, G. M. Knudsen, K. F. Medzihradszky, and P. R. Ortiz de Montellano “The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis Catalase-Peroxidase (KatG): Autocatalytic Formation and Effect on Enzyme Catalysis and Spectroscopic Properties” J. Biol. Chem. 2005, 280, 22651-22663.

10. R. A. Ghiladi, H.-w. Huang, P. Moënne-Loccoz, J. Stasser, N. J. Blackburn, A. S. Woods, R. J. Cotter, C. D. Incarvito, A. L. Rheingold, and K. D. Karlin “Heme-copper/dioxygen Adduct Formation Relevant to Cytochrome c Oxidase: Spectroscopic Characterization of [(6L)FeIII-(O22-)-CuII]+J. Biol. Inorg. Chem. 2005, 10, 63-77.

9. R. A. Ghiladi, D. E. Cabelli, and P. R. Ortiz de Montellano “Superoxide Reactivity of KatG: Insights into Isoniazid Resistance Pathways in TB” J. Am. Chem. Soc. 2004, 126, 4722-4723.

8. D. W. Thompson, R. M. Kretzer, E. L. Lebeau, D. V. Scaltrio, R. A. Ghiladi, K.-C. Lam, A. L. Rheingold, K. D. Karlin, and G. J. Meyer “Synthesis, Characterization, and Laser Flash Photolysis Reactivity of a Reduced Carbonmonoxy Heme Complex” Inorg. Chem. 2003, 42, 5211-5218.

7. R. M. Kretzer, R. A. Ghiladi, E. L. Lebeau, H.-C. Liang, and K. D. Karlin “Synthesis and Characterization of Reduced Heme and Heme/Copper Carbonmonoxy Species” Inorg. Chem. 2003, 42, 3016-3025.

6. R. A. Ghiladi and K. D. Karlin “Low-Temperature UV-Visible and NMR Spectroscopic Investigations of O2 Binding to (6L)FeII, a Ferrous Heme Bearing Covalently Tethered Axial Pyridine Ligands” Inorg. Chem. 2002, 41, 2400-2407.

5. R. A. Ghiladi, R. M. Kretzer, I. Guzei, A. L. Rheingold, Y.-M. Neuhold, K. R. Hatwell, A. D. Zuberbühler, and K. D. Karlin “(F8TPP)FeII/O2 Reactivity Studies {F8TPP = Tetrakis(2,6-difluorophenyl)porphyrinate(2-)}: Spectroscopic (UV-Visible and NMR) and Kinetic Study of Solvent-Dependent (Fe/O2 = 1:1 or 2:1) Reversible O2-Reduction and Ferryl Formation” Inorg. Chem. 2001, 40, 5754-5767.

4. R. A. Ghiladi, K. R. Hatwell, K. D. Karlin, H.-w. Huang, P. Moënne-Loccoz, C. Krebs, B. H. Huynh, L. Marzilli, R. J. Cotter, S. Kaderli, and A. D. Zuberbühler “Dioxygen Reactivity of Mononuclear Heme and Copper Components Yielding A High-Spin Heme-Peroxo-Cu Complex” J. Am. Chem. Soc. 2001, 123, 6183-6184.

3. P. Moënne-Loccoz, O. M. H. Richter, H.-w. Huang, I. M. Wasser, R. A. Ghiladi, and K. D. Karlin “Nitric Oxide Reductase from Paracoccus Denitrificans Contains an Oxo-Bridged Heme/Non-Heme Diiron Center” J. Am. Chem. Soc. 2000, 122, 9344-9345.

2. R. A. Ghiladi, T. D. Ju, D.-H. Lee, P. Moënne-Loccoz, S. Kaderli, Y.-M. Neuhold, A. D. Zuberbühler, A. S. Woods, R. J. Cotter, and K. D. Karlin “Formation and Characterization of a High-Spin Heme-Copper (Peroxo) Complex” J. Am. Chem. Soc. 1999, 121, 9885-9886.

1. T. D. Ju, R. A. Ghiladi, D.-H. Lee, G. P. F. van Strijdonck, A. S. Woods, R. J. Cotter, V. G. Young Jr., and K. D. Karlin “Dioxygen Reactivity of Fully Reduced [LFeII…CuI]+ Complexes Utilizing Tethered Tetraarylporphyrins: Active Site Models for Heme-Copper Oxidases” Inorg. Chem. 1999, 38, 2244-2245.